IRF4 regulates myeloid-derived suppressor cells expansion and function in Schistosoma japonicum-infected mice.

ABSTRACT:

Background

Interferon regulatory factor 4 (IRF4) is a crucial member of the IRF family of transcription factors and is pivotal in orchestrating the body's defense against tumors and infections by modulating the differentiation and functionality of immune cells. The role of IRF4 in mice during Schistosoma japonicum infection, as well as the effects of IRF4 deficiency on myeloid-derived suppressor cells (MDSCs), remains inadequately understood.

Methods

Hematoxylin and eosin staining was used to evaluate the pathological damage in different organs of mice following infection with S. japonicum. Flow cytometry was employed to study the effect of IRF4 on the proliferation and function of myeloid-derived suppressor cells (MDSCs) in S. japonicum-infected mice.

Results

Knockou

SUBMITTER: Zhou L 

PROVIDER: S-EPMC11605884 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature