Association of childhood-adulthood body size trajectories with risk of micro- and macrovascular complications among individuals with type 2 diabetes: a prospective study.

ABSTRACT:

Aims

This study aimed to investigate the association between childhood-adulthood body size trajectories and the risk of micro- and macrovascular complications in individuals with type 2 diabetes (T2D) using data from the UK Biobank.

Methods

Childhood body size (average, thinner, and plumper) was self-reported for age 10, and adulthood body size (normal weight, overweight, obesity) was measured using body mass index at baseline. We defined nine body size trajectories by combining childhood and adulthood body size categories. Cox regression models were used to assess the association between these trajectories and the risk of diabetic complications.

Results

Among 22,123 participants with T2D, 4,693 developed microvascular complications, and 3,640 developed macrovascular

SUBMITTER: Zeng X 

PROVIDER: S-EPMC11605916 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature