Differential regulation of magnesium transporters Slc41, Cnnm and Trpm6-7 in the kidney of salmonids may represent evolutionary adaptations to high salinity environments.

ABSTRACT: Magnesium is important for enzymatic reactions and physiological functions, and its intracellular concentration is tightly regulated. Atlantic salmon has the ability to handle large changes in environmental Mg²⁺ concentration when migrating between freshwater and seawater habitats, making it a relevant model to investigate Mg²⁺ homeostasis. Parr-smolt transformation (PST) is a life history transition which prepares the freshwater juvenile for the marine environment. The kidney is one of the key organs involved in handling higher salt load in teleosts. Though several key Mg²⁺ transport families (SLC41, CNNM and TRPM6-7) have recently been identified in mammals and a few fishes, the molecular bases of Mg²⁺ homeostasis in salmon are not known. We fo

SUBMITTER: Takvam M 

PROVIDER: S-EPMC11605958 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature