Albumin-seeking near-infrared-II probe evaluating blood-brain barrier disruption in stroke.

ABSTRACT:

Background

Blood-brain barrier (BBB) disruption after stroke is closely associated with brain tissue edema and neuronal injury, which requires accurate assessment. However, there is a lack of appropriate BBB imaging modality in vivo. As albumin in the blood could cross the damaged BBB into brain tissue after stroke, it serves as a biomarker for BBB disruption. Therefore, we aimed to develop an albumin-seeking near-infrared (NIR) probe to assess BBB disruption in stroke.

Results

We proposed a chemoselective strategy for seeking albumin with NIR dyes and identified an optimal probe to evaluate BBB disruption in stroke. The probe combined a NIR fluorescent dye with inherent albumin-targeting moieties and exhibited high affinity and selectivity for binding to albumin. Using a mo

SUBMITTER: Zhu HJ 

PROVIDER: S-EPMC11606037 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature