Ciprofol prevents ferroptosis in LPS induced acute lung injury by activating the Nrf2 signaling pathway.

ABSTRACT:

Background

Patients who suffered from sepsis-induced acute lung injury (ALI) always need sedation for mechanical ventilation in intensive care unit (ICU). Ciprofol(Cip), a novel intravenous anesthetic, was revealed to have anti-inflammatory and antioxidative properties. Ferroptosis, categorized as a type of newly non-apoptotic cell death, participates in the development of lung injury. This study aimed to identify the effect of ciprofol on sepsis-induced ALI and to determine whether ferroptosis is involved.

Methods and results

To create ALI models, MLE12 alveolar epithelial. Cells and lipopolysaccharide (LPS)-stimulated C57BL/6J mice were used. Our results displyed that Cip reduced lung injury and ferroptosis. In the LPS-induced sepsis mice model, Cip pretreatment partially

SUBMITTER: Zhao Q 

PROVIDER: S-EPMC11606060 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature