Gut microbiota and mycobiota change with feeding duration in mice on a high-fat and high-fructose diet.

ABSTRACT:

Background

Metabolic dysfunction-associated fatty liver disease (MAFLD), formerly known as nonalcoholic fatty liver disease (NAFLD), is becoming the most common chronic liver disease. The gut microbiome is regarded to play a crucial role in MAFLD, but the specific changes of gut microbiome, especially fungi, in different stages of MAFLD are not well understood. This study aimed to observe the longitudinal changes of colon bacteria and fungi of mice at different feeding duration of a high-fat and high-fructose diet (HFHFD), and explore the association between the changes and the progression of MAFLD.

Methods

Twenty-eight male C57BL6J mice were randomly assigned to the normal diet (ND) group and HFHFD group. At the 8th and 16th weeks, mice were sacrificed to compare the divers

SUBMITTER: Zheng R 

PROVIDER: S-EPMC11606092 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature