Multi-omics landscape of childhood simple obesity: novel insights into pathogenesis and biomarkers discovery.

ABSTRACT:

Background

The increasing incidence of childhood obesity annually has led to a surge in physical and mental health risks, making it a significant global public health concern. This study aimed to discover novel biomarkers of childhood simple obesity through integrative multi-omics analysis, uncovering their potential connections and providing fresh research directions for the complex pathogenesis and treatment strategies.

Methods

Transcriptome, untargeted metabolome, and 16 S rDNA sequencing were conducted on subjects to examine transcripts, metabolites in blood, and gut microflora in stool.

Results

Transcriptomic analysis identified 599 differentially expressed genes (DEGs), of which 25 were immune-related genes, and participated in immune pathways such as antimicrob

SUBMITTER: Ren Y 

PROVIDER: S-EPMC11606102 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature