TbpB-based oral mucosal vaccine provides heterologous protection against Glasser's disease caused by different serovars of Spanish field isolates of Glaesserella parasuis.

ABSTRACT:

Background

Glaesserella parasuis (G. parasuis) is the primary agent of Glässer's disease, significantly affecting nursery and early fattening piglets. Current prophylactic measures, mainly serovar-specific bacterins administered to sows, are limited by maternal immunity, which can interfere with active immunization in piglets. Subunit vaccines containing G. parasuis-specific antigenic molecules show promise but are not yet commercially available. Transferrin-binding proteins (Tbp), which enable G. parasuis to acquire iron in low-iron environments like mucosal surfaces, have been proposed as potential vaccine antigens. The mucosal administration of a TbpB-based subunit vaccine could provide a promising solution to overcome the limitations posed by maternal immunity, offering an effe

SUBMITTER: Gonzalez-Fernandez A 

PROVIDER: S-EPMC11606180 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature