Causal roles of dietary structure and types on prostate cancer risk: A mendelian randomization study.

ABSTRACT:

Background

Numerous observational studies have reported a strong link between dietary habits and the risk of prostate cancer. However, these studies are susceptible to confounding factors. To address this question, we conducted a two-sample Mendelian randomization (MR) study to explore the causal relationship between dietary habits and prostate cancer.

Methods

Genetic data for 25 different diet types were obtained from UK Biobank. Summary-level data on dietary composition and prostate cancer were obtained from a large genome-wide association study (GWAS). We employed the inverse variance weighted (IVW) for the primary analysis to examine the causal relationship between dietary components, dietary types, and prostate cancer. We also conducted sensitivity analyses using the St

SUBMITTER: Li C 

PROVIDER: S-EPMC11606238 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature