Shared Genetic Links Between Nonalcoholic Fatty Liver Disease and Coronary Artery Disease.

ABSTRACT:

Background

Epidemiological and clinical studies have shown that there is a co-morbidity between nonalcoholic fatty liver disease (NAFLD) and coronary artery disease (CAD).

Methods

In this study, we utilized linkage disequilibrium score regression (LDSC) to evaluate the genetic correlation between non-alcoholic fatty liver disease (NAFLD) and coronary artery disease (CAD). We identified pleiotropic loci and genes using SNP-Level PLACO analysis. Following this, MAGMA gene set enrichment analysis was conducted to assess the biological significance of these pleiotropic genes. Finally, a two-sample two-way Mendelian randomization (MR) analysis was performed to evaluate causal relationships between NAFLD and CAD.

Results

We found a significant genetic correlation between NA

SUBMITTER: Di H 

PROVIDER: S-EPMC11606392 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature