Omega-3 Polyunsaturated Fatty Acids as a Protective Factor for Myopia.

ABSTRACT:

Purpose

Animal models suggest omega-3 polyunsaturated fatty acids (PUFAs) may protect against myopia by modulating choroidal blood perfusion, but clinical evidence is scarce and mixed. We aimed to determine the causality between omega-3 PUFAs and myopia using Mendelian randomization (MR) analysis.

Design

Two-sample MR analysis.

Methods

Exposures are genetically predicted plasma levels of 18 fatty acid (FA)-related traits. Spherical equivalent refraction (SER) and axial length were used as measurements of myopia. Genome-wide association study summary data on plasma levels of 18 FA-related traits (n=115,006), refractive spherical equivalent (n=351,091), axial length (n=69,945), and choroidal thickness (n=44,823) were sourced from the UK Biobank, the Genetic Epidemiology

SUBMITTER: Xue CC 

PROVIDER: S-EPMC11606739 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature