Comparative Effectiveness and Safety of Direct Oral Anticoagulants vs Warfarin among Nursing Home Residents with Atrial Fibrillation: A Retrospective Cohort Study.

ABSTRACT:

Objective

Residents of nursing homes are usually excluded from clinical trials, including trials to assess treatments for common conditions such as nonvalvular atrial fibrillation (NVAF). We aimed to quantify the real-world comparative safety and effectiveness of direct-acting oral anticoagulants (DOACs) vs warfarin among nursing home residents with NVAF.

Design

Retrospective cohort study using 100% national Minimum Data Set and linked Medicare claims from January 2011 through December 2018.

Setting and participants

Long-term care nursing home residents aged ≥66 years enrolled in fee-for-service Medicare. We included individuals diagnosed with NVAF newly initiating oral anticoagulants.

Methods

We identified exposure to DOACs (apixaban, dabigatran, rivaroxaban,

SUBMITTER: Mehta HB 

PROVIDER: S-EPMC11606742 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature