Improved Diffusion-Weighted Hyperpolarized ¹²⁹Xe Lung MRI with Patch-Based Higher-Order, Singular Value Decomposition Denoising.

ABSTRACT:

Rationale and objectives

Hyperpolarized xenon (¹²⁹Xe) MRI is a noninvasive method to assess pulmonary structure and function. To measure lung microstructure, diffusion-weighted imaging-commonly the apparent diffusion coefficient (ADC)-can be employed to map changes in alveolar-airspace size resulting from normal aging and pulmonary disease. However, low signal-to-noise ratio (SNR) decreases ADC measurement certainty, and biases ADC to spuriously low values. Further, these challenges are most severe in regions of the lung where alveolar simplification or emphysematous remodeling generate abnormally high ADCs. Here, we apply Global Local Higher Order Singular Value Decomposition (GLHOSVD) denoising to enhance image SNR, thereby reducing uncertainty and bias in diffusion me

SUBMITTER: Soderlund SA 

PROVIDER: S-EPMC11606792 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature