Exploring Dietary Factors and Esophageal Adenocarcinoma: Insights From Mendelian Randomization Study.

ABSTRACT: Esophageal adenocarcinoma and diet are not well understood to be associated. We conducted Mendelian randomization analysis using 18 dietary factors as exposures (primarily including fruit consumption, vegetable consumption, alcohol consumption, meat consumption, tea intake, fish intake, etc.), with esophageal adenocarcinoma as the outcome. The IVW method was the leading method used for detecting causal links. Cochran's Q test was utilized to assess heterogeneity, the intercept of the MR-Egger method was used to assess the presence of horizontal pleiotropy, and the existence of outliers was identified via the MR-Presso method. This study identified that both alcohol intake frequency (OR = 1.375, p = 0.0216) and coffee intake (OR = 2.680, p = 0.0304) were linked to a hei

SUBMITTER: Liu X 

PROVIDER: S-EPMC11606852 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature