<i>Semen Trigonellae</i> alleviates LPS-induced depressive behavior via enhancing the abundance of <i>Ligilactobacillus</i> spp.

ABSTRACT: The rising incidence rate of depression presents a substantial threat to human well-being. Semen Trigonellae (ST), the dried mature seeds of Trigonella foenum-graecum L., has a long-standing traditional reputation for alleviating anxiety and hopelessness. However, the anti-depressant mechanism of ST remains poorly understood. This study aimed to assess ST's anti-depressant, as well as explore its potential mechanism from a gut microbial aspect. The Kunming mice were challenged by lipopolysaccharide (LPS) to induce depression-like behavior and then orally administrated with aqueous extract of ST. The behavioral test, and hippocampal and serum biochemical indicators were detected to assess anti-depressant effect of ST. We utilized full-length 16S rRNA gene sequencing to investi

SUBMITTER: Chang W 

PROVIDER: S-EPMC11606864 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature