RNA m6A methylation regulatory mechanism of resveratrol in premature senescence cells.

ABSTRACT: Resveratrol, a natural compound found in various plants, is known for its anti-inflammatory, antioxidant, and senescence-delaying properties. RNA N6-methyladenosine (m6A) methylation plays a crucial role in oxidative stress and premature cellular senescence processes and is closely associated with age-related disorders. However, the anti-premature senescence via RNA m6A methylation mechanism of resveratrol is still not fully understood. In this study, based on premature senescence model of human embryonic lung fibroblasts (HEFs) induced by hydrogen peroxide (H₂O₂), a widely accepted model of premature senescence caused by oxidative stress, we explored the anti-aging regulatory effects of resveratrol at the RNA m6A methylation level. Our data suggested that resveratrol

SUBMITTER: Zhang X 

PROVIDER: S-EPMC11606896 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature