Timing and risk factors associated with acute kidney injury in infants with necrotizing enterocolitis.

ABSTRACT:

Objective

To evaluate the prevalence, onset, risk factors, and mortality associated with acute kidney injury (AKI) in infants with necrotizing enterocolitis (NEC).

Design/methods

Retrospective study at 2 centers in infants with NEC, with/without AKI. AKI assessed by serum creatinine and urine output. Statistical tests used included t, Mann-Whitney U, Chi-square, and Fisher Exact tests.

Results

Among 80 eligible infants with NEC, 56 (70%) had AKI. Median onset of NEC was day 15, with median AKI onset two days (IQR, -5.75 to 0) prior to NEC onset. Vasopressors were significantly more likely to be used in infants with NEC and AKI (p = 0.009). Increased mortality (p = 0.01) was noted in infants with NEC and AKI.

Conclusions

The onset of AKI mostly precedes NEC onse

SUBMITTER: Lingasubramanian G 

PROVIDER: S-EPMC11606910 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature