Maternal, neonatal, and nutritional risk factors for medical and surgical necrotizing enterocolitis.

ABSTRACT:

Objective

To identify maternal and neonatal risk factors associated with progression to surgery or death after diagnosis of NEC.

Study design

Forty-seven demographic and clinical factors were evaluated across 216 validated cases of NEC occurring between 2010-2020. Nutrition at NEC onset was evaluated in 149 cases. The binary outcome of surgical NEC (progressing to surgery or death) vs. medical NEC (resolved with antibiotic/bowel rest) was compared across variables.

Results

Elevated CRP, rapidly decreasing platelet counts, inotropic medication, intubation, and positive blood cultures within 24 h of diagnosis were associated with progression to surgery/death. Infants with surgical NEC had higher abdominal circumferences at birth. Maternal milk intake and receipt of huma

SUBMITTER: Essex C 

PROVIDER: S-EPMC11606919 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature