The putative error prone polymerase REV1 mediates DNA damage and drug resistance in Candida albicans.

ABSTRACT: Antimicrobial-induced DNA damage, and subsequent repair via upregulation of DNA repair factors, including error-prone translesion polymerases, can lead to the increased accumulation of mutations in the microbial genome, and ultimately increased risk of acquired mutations associated with antimicrobial resistance. While this phenotype is well described in bacterial species, it is less thoroughly investigated amongst microbial fungi. Here, we monitor DNA damage induced by antifungal agents in the fungal pathogen Candida albicans, and find that commonly used antifungal drugs are able to induce DNA damage, leading to the upregulation of transcripts encoding predicted error-prone polymerases and related factors. We focus on REV1, encoding a putative error-prone polymerase, and find that while de

SUBMITTER: Agyare-Tabbi MR 

PROVIDER: S-EPMC11606924 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature