An integrated single-cell atlas of blood immune cells in aging.

ABSTRACT: Recent advances in single-cell technologies have facilitated studies on age-related alterations in the immune system. However, previous studies have often employed different marker genes to annotate immune cell populations, making it challenging to compare results. In this study, we combined seven single-cell transcriptomic datasets, comprising more than a million cells from one hundred and three donors, to create a unified atlas of human peripheral blood mononuclear cells (PBMC) from both young and old individuals. Using a consistent set of marker genes for immune cell annotation, we standardized the classification of immune cells and assessed their prevalence in both age groups. The integrated dataset revealed several consistent trends related to aging, including a decline in CD8^+</

SUBMITTER: Filippov I 

PROVIDER: S-EPMC11606963 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature