VCAM-1⁺ Mesenchymal Stem/Stromal Cells Reveal Preferable Efficacy Upon an Experimental Autoimmune Encephalomyelitis Mouse Model of Multiple Sclerosis Over the VCAM-1^- Counterpart.

ABSTRACT: Despite the considerable progress in mesenchymal stem/stromal cells (MSCs)-based novel intervention of multiple sclerosis (MS), yet the disease-modifying effect of VCAM-1^- MSCs and novel VCAM-1⁺ counterpart is largely obscure. In this study, we took advantage of the EAE mouse model and VCAM-1⁺ human umbilical cord-derived MSCs (hUC-MSCs) for the evaluation of the therapeutic effect of systematic MSCs infusion. On the one hand, we compared the protective effect of VCAM-1^- and VCAM-1⁺ hUC-MSCs against the clinical symptoms, demyelination, active glia cells and neuroinflammation in EAE mice by conducting multifaceted detections upon spinal cord and brain tissues. On the other hand, we conducted RNA-sequencing (RNA-SEQ) and multidimensiona

SUBMITTER: Liu H 

PROVIDER: S-EPMC11607028 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature