Gut microbiota and epigenetic age acceleration: a bi-directional Mendelian randomization study.

ABSTRACT:

Background

The gut microbiota is closely related to aging, but the genetic relationship between gut microbiota and aging has not been well investigated. The aim of the study was to explore the association of microbiota with epigenetic age acceleration (EAA) using the Mendelian randomization.

Method

The independent genetic instruments of gut microbiota were obtained from MiBioGen consortium and the Dutch Microbiome Project. EAA data were derived from genome-wide association study. To assess the causal relationship between gut microbiota and EAA, we applied four different methods of Mendelian Randomization (MR) analysis: the inverse variance weighted method (IVW), the MR-Egger regression, the weighted median analysis (WMA), and the weighted mode. Furthermore, sensitivity analy

SUBMITTER: Xu H 

PROVIDER: S-EPMC11607049 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature