Age-associated imbalance in immune cell regeneration varies across individuals and arises from a distinct subset of stem cells.

ABSTRACT: The age-associated decline in immunity manifests as imbalanced adaptive and innate immune cells, which originate from the aging of the stem cells that sustain their regeneration. Aging variation across individuals is well recognized, but its mechanism remains unclear. Here, we used high-throughput single-cell technologies to compare mice of the same chronological age that exhibited early or delayed immune aging phenotypes. We found that some hematopoietic stem cells (HSCs) in early aging mice upregulated genes related to aging, myeloid differentiation, and stem cell proliferation. Delayed aging was instead associated with genes involved in stem cell regulation and the response to external signals. These molecular changes align with shifts in HSC function. We found that the lineage biases o

SUBMITTER: Nogalska A 

PROVIDER: S-EPMC11607082 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature