New direction: identification of immunoinflammatory subtypes and potential therapeutic targets for cholangiocarcinoma.

ABSTRACT:

Background

Cholangiocarcinoma (CHOL) is a rare cancer with low survival rates. Despite advances in precision medicine targeting molecular subtypes, the immune subtypes of CHOL remain poorly understood. This study aimed to identify immune subtypes of CHOL and investigate their implications in the metabolic regulation of macrophage functions in inflammation.

Methods

We conducted a comprehensive analysis of transcriptome and single-cell sequencing data from multiple databases to classify the immune subtypes of CHOL. Immune cell infiltration within the tumor microenvironment (TME) and the metabolic pathways involved in macrophage activation and polarization were also analyzed.

Results

Two distinct immune subtypes, immune-infiltrated CS1 and immune-depleted CS2, were ident

SUBMITTER: Chen Z 

PROVIDER: S-EPMC11607260 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature