Multiple myeloma long-term survivors exhibit sustained immune alterations decades after first-line therapy.

ABSTRACT: The long-term consequences of cancer and its therapy on the patients' immune system years after cancer-free survival remain poorly understood. Here, we present an in-depth characterization of the bone marrow immune ecosystem of multiple myeloma long-term survivors, from initial diagnosis up to 17 years following a single therapy line and cancer-free survival. Using comparative single-cell analyses combined with molecular, genomic, and functional approaches, we demonstrate that multiple myeloma long-term survivors exhibit pronounced alterations in their bone marrow microenvironment associated with impaired immunity. These immunological alterations were frequently linked to an inflammatory immune circuit fueled by the long-term persistence or resurgence of residual myeloma cells. Notably, ev

SUBMITTER: Lutz R 

PROVIDER: S-EPMC11607340 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature