CD30 influences germinal center B-cell dynamics and the expansion of IgG1-switched B cells.

ABSTRACT: Initially, identified as a Hodgkin lymphoma marker, CD30 was subsequently detected on a subset of human B cells within and around germinal centers (GCs). While CD30 expression is typically restricted to a few B cells, expansion of CD30-expressing B cells occurs in certain immune disorders and during viral infections. The role of CD30 in B cells remains largely unclear. To address this gap in knowledge, we established a conditional CD30-knockin mouse strain. In these mice, B-cell-specific CD30 expression led to a normal B-cell phenotype in young mice, but most aged mice exhibited significant expansion of B cells, T cells and myeloid cells and increased percentages of GC B cells and IgG1-switched cells. This may be driven by the expansion of CD4⁺ senescence-associated T cells and

SUBMITTER: Wang Y 

PROVIDER: S-EPMC11607414 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature