Granzyme K⁺CD8⁺ T cells interact with fibroblasts to promote neutrophilic inflammation in nasal polyps.

ABSTRACT: Sophisticated interactions between stromal and immune cells play crucial roles in various biological and pathological processes. In chronic rhinosinusitis with nasal polyps (CRSwNP), the upper airway inflammation in many patients is driven by T_H2, ILC2, and eosinophils, thus being treated with glucocorticoids and anti-type 2 inflammation biologics. The resistance to these therapies is often associated with neutrophilic inflammation, which has also been widely identified in CRSwNP, but the underlying mechanisms remain unclear. Using single-cell analysis, spatial transcriptomics, and T-cell receptor sequencing, we identify an increased presence of granzyme K⁺(GZMK⁺) CD8⁺ T cells in NPs, which possess a phenotype distinct from the cytotoxic GZMB

SUBMITTER: Guo CL 

PROVIDER: S-EPMC11607458 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature