Short-term changes in human metabolism following a 5-h delay of the light-dark and behavioral cycle.

ABSTRACT: Experimental inversion of circadian and behavioral rhythms by 12 h adversely affects markers of metabolic health. We investigated the effects of a more modest 5-h delay in behavioral cycles. Fourteen participants completed an 8-day in-patient laboratory protocol, with controlled sleep-wake opportunities, light-dark cycles, and diet. The 5-h delay in behavioral cycles was induced by delaying sleep opportunity. We measured melatonin to confirm central circadian phase, fasting markers and postprandial metabolism, energy expenditure, subjective sleepiness, and appetite, throughout the waking period. After the phase delay, there was slower gastric emptying at breakfast, lower fasting plasma glucose, higher postprandial plasma glucose and triglycerides, and lower thermic effect of feeding. Any c

SUBMITTER: Flanagan A 

PROVIDER: S-EPMC11607541 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature