Structural and molecular characteristics of weight-bearing volar skin can be reconstituted by micro skin tissue column grafting.

ABSTRACT: For patients with lower limb amputations, prostheses are immensely helpful for mobility and the ability to perform job-related or recreational activities. However, the skin covering the amputation stump is typically transposed from adjacent areas of the leg and lacks the weight-bearing capacity that is only found in the specialized skin covering the palms and soles (a.k.a. volar skin). As a result, the skin tissue in direct contact with the prosthesis frequently breaks down, leading to the development of painful sores and other complications that limit, and often preclude, the use of prostheses. Transplanting volar skin onto amputation stumps could be a solution to these problems, but traditional skin transplantation techniques cause substantial morbidity at the donor site, such as pain an

SUBMITTER: Fuchs C 

PROVIDER: S-EPMC11607627 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature