Exploring the anti-inflammatory effects of acupuncture and Chinese herbal medicine targeting the miRNA-146a/IRAK1/JNK1 pathway in an environmental dry eye rat model.

ABSTRACT:

Background

Dry eye syndrome has emerged as a subject of substantial significance in the field of ophthalmological research, prompting an exploration of therapeutic approaches.

Objective

This study investigates the anti-inflammatory effects of acupuncture and Chinese herbal medicine in an environmental dry eye (EDE) rat model, focusing on the intricate "miRNA-146a/IRAK1/JNK1" pathway.

Material and methods

The experimental groups included Control, Model, 0.3% Sodium Hyaluronate (SH), Acupuncture (Acup), Herbal medicine (YQCM), and Combined therapy (Acup + YQCM), each aimed at understanding their efficacy in addressing EDE complexities. Treatment efficacy was gauged using various parameters.

Results

Acupuncture and herbal medicine intervention demonstrated signifi

SUBMITTER: Zhao L 

PROVIDER: S-EPMC11607646 | biostudies-literature | 2024 Nov-Dec

REPOSITORIES: biostudies-literature