Clinical and Preclinical Methods of Heat-Stabilization of Human Vaccines.

ABSTRACT: Vaccines have historically faced challenges regarding stability, especially in regions lacking a robust cold chain infrastructure. This review delves into established and emergent techniques to improve the thermostability of vaccines. We discuss the widely practiced lyophilization method, effectively transforming liquid vaccine formulations into a solid powdered state, enhancing storage and transportation ability. However, potential protein denaturation during lyophilization necessitates alternative stabilization methods. Cryoprotectants, namely, starch and sugar molecules, have shown promise in protecting vaccine antigens and adjuvants from denaturation and augmenting the stability of biologics during freeze-drying. Biomineralization, a less studied yet innovative approach, utilizes inorg

SUBMITTER: Williamson GL 

PROVIDER: S-EPMC11607726 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature