Effects of sacubitril/valsartan on renal function and outcome in patients with heart failure and reduced ejection fraction: an Italian cohort study.

ABSTRACT:

Background

Sacubitril/valsartan (S/V) is a cornerstone treatment for heart failure (HF). Beneficial effects on hospitalization rates, mortality, and left ventricular remodeling have been observed in patients with heart failure and reduced ejection fraction (HFrEF). Despite the positive results, the influence of S/V on renal function during long-term follow-up has received little attention.

Aims

We investigated the long-term effects of S/V therapy on renal function in a large cohort of patients with HFrEF. Additionally, we examined the effects of the drug in patients with chronic kidney disease (CKD) compared to those with preserved renal function and identified primary risk characteristics.

Methods

We studied 776 outpatients with HFrEF and left ventricular ejection fr

SUBMITTER: Palazzuoli A 

PROVIDER: S-EPMC11607766 | biostudies-literature | 2024 Jan-Dec

REPOSITORIES: biostudies-literature