CRHBP, a novel multiple cancer biomarker connected with better prognosis and anti-tumorigenicity.

ABSTRACT:

Background

The corticotropin-releasing hormone-binding protein (CRHBP) plays a crucial role in regulating corticotropin release. Little is known about the role of CRHBP, a major regulator of neuroendocrine, autonomic, and stress adaptation, in tumors. In this study, we aimed to investigate the clinical and molecular landscapes of CRHBP in various types of tumors.

Methods

We investigated the role of CRHBP in different types of tumors using publicly available databases and performed a comparative expression analysis of CRHBP-related genes in pan-cancer prognosis using methylation profiling, tumor-infiltrating immune cell expression analysis, gene enrichment analysis, and protein-protein interaction analysis, identified common pathways, and in vitro evaluation.

Results

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SUBMITTER: Yoo W 

PROVIDER: S-EPMC11607943 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature