Network integration and segregation changes in schizophrenia: impact of electroconvulsive therapy.

ABSTRACT: Studies have confirmed brain network topology disruption in schizophrenia (SZ). Electroconvulsive therapy (ECT) rapidly improves acute psychiatric symptoms, yet the exact mechanism by which it impacts brain network topology in SZ patients remains unclear. This study aims to explore topological changes in SZ patients' whole-brain functional networks during ECT, ultimately elucidating implicated neurological mechanisms. This study collected resting-state functional magnetic resonance imaging (rs-fMRI) data from 53 patients with schizophrenia before and after ECT, as well as data from 46 age-, gender-, and education-matched healthy control participants (HC). Using the Brainnetome Atlas, brain functional networks were constructed for each participant. Graph theory methods were applied to measu

SUBMITTER: Ding N 

PROVIDER: S-EPMC11607971 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature