Increased Platelet Adhesiveness in Patients with Venous Thromboembolic Disease.

ABSTRACT: Background  Association between global platelet function and the risk of venous thromboembolic disease (VTE) has been proposed, though the mechanisms do not involve increased platelet aggregation. However, platelet adhesiveness has not been systematically explored in VTE patients. Objectives  To evaluate platelet adhesive functions in VTE patients. Methods  Platelet adhesion was evaluated by using whole blood samples from VTE patients, selected based on short closure times on the PFA-100 ( n  = 54), and matched healthy individuals ( n  = 57) in: (i) the PFA-100, (ii) a cone plate analyzer (CPA), on a plastic surface, (iii) microfluidic devices, with two- and three-dimensional evaluation, and (iv) membrane glycoprotein analysis. Intraplatelet signaling was evaluated in isolated collagen typ

SUBMITTER: Martinez-Sanchez J 

PROVIDER: S-EPMC11608120 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature