Sleep Deprivation Effects on Brain State Dynamics Are Associated With Dopamine D₂ Receptor Availability Via Network Control Theory.

ABSTRACT:

Background

Sleep deprivation (SD) negatively affects brain function. Most brain imaging studies have investigated the effects of SD on static brain function. SD effects on functional brain dynamics and their relationship with molecular changes remain relatively unexplored.

Methods

We used functional magnetic resonance imaging to examine resting-brain state dynamics after one night of SD compared with rested wakefulness (N = 41) and assessed the association of brain state dynamics with striatal brain dopamine D₂ receptor availability measured by positron emission tomography [¹¹C]raclopride using network control theory.

Results

SD reduced dwell time and persistence probabilities, with the strongest effects in two brain states, one characterized by

SUBMITTER: Zhang R 

PROVIDER: S-EPMC11608148 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature