Transthyretin Orchestrates Vitamin B12-Induced Stress Resilience.

ABSTRACT:

Background

Chronic stress significantly contributes to mood and anxiety disorders. Previous data suggest a correlative connection between vitamin B12 supplementation, depression, and stress resilience. However, the underlying mechanisms are still poorly understood.

Methods

Using the chronic variable stress mouse model coupled with RNA sequencing, we identified vitamin B12-induced transcriptional changes related to stress resilience. Using viral-mediated gene transfer and in vivo epigenome editing, we revealed a functional pathway linking vitamin B12, DNA methylation (DNAme), and depression-like symptoms.

Results

We identified Ttr (transthyretin) as a key sex-specific target of vitamin B12 in chronic stress. Accordingly, TTR expression was increased postmortem in the p

SUBMITTER: Stein G 

PROVIDER: S-EPMC11608149 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature