Construction and validation of prognostic models for young cervical cancer patients: age stratification based on restricted cubic splines.

ABSTRACT: Cervical cancer (CC) ranks as the second highest cause of morbidity and mortality among young women; however, there are currently no age-specific definitions for young cervical cancer or prognostic models tailored to this demographic. Data on CC diagnosed between 2000 and 2019 were extracted from the Surveillance, Epidemiology, and End Results (SEER) database. Age stratification is based on the relationship between age and cancer-specific mortality, as demonstrated by restricted cubic spline analyses (RCS). Cox proportional hazards regression analyses were employed to identify independent prognostic factors in the young CC group. Two novel nomograms for this population were developed and validated using an external validation cohort obtained from a local hospital database, evaluated with c

SUBMITTER: Gong Y 

PROVIDER: S-EPMC11608258 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature