SARS-CoV-2 human challenge reveals biomarkers that discriminate early and late phases of respiratory viral infections.

ABSTRACT: Blood transcriptional biomarkers of acute viral infections typically reflect type 1 interferon (IFN) signalling, but it is not known whether there are biological differences in their regulation that can be leveraged for distinct translational applications. We use high frequency sampling in the SARS-CoV-2 human challenge model to show induction of IFN-stimulated gene (ISG) expression with different temporal and cellular profiles. MX1 gene expression correlates with a rapid and transient wave of ISG expression across all cell types, which may precede PCR detection of replicative infection. Another ISG, IFI27, shows a delayed but sustained response restricted to myeloid cells, attributable to gene and cell-specific epigenetic regulation. These findings are reproducible in experimental and nat

SUBMITTER: Rosenheim J 

PROVIDER: S-EPMC11608262 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature