A computational model that integrates unrestricted callus growth, mechanobiology, and angiogenesis can predict bone healing in rodents.

ABSTRACT: We present a computational model that integrates mechanobiological regulations, angiogenesis simulations and models natural callus development to simulate bone fracture healing in rodents. The model inputs include atomic force microscopy values and micro-computed tomography on the first-day post osteotomy, which, combined with detailed finite element modeling, enables scrutinizing mechanical and biological interactions in early bone healing and throughout the healing process. The model detailed mesenchymal stem cell migration patterns, which are essential for tissue transformation and vascularization during healing, indicating the vital role of blood supply in the healing process. The model predicted bone healing in rodents (n = 48) over 21 days, matching daily tissue development with hist

SUBMITTER: Hedayatzadeh Razavi A 

PROVIDER: S-EPMC11608358 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature