Modified neuroimmune processes and emotional behaviour in weaned and late adolescent male and female mice born via caesarean section.

ABSTRACT: Elective and emergency Caesarean section (C-section) procedures are on the rise, exceeding the recommended guidelines by the World Health Organization. Higher morbidities and long-term health conditions are correlated to C-section deliveries, including neurodevelopmental disorders. During C-section delivery, newborns are not exposed to the vaginal commensal flora, which impedes the early establishment of the gut microbiota. The latter is essential for adequate neuro-immune processes to take place during infancy. In this study, we used a validated model of mice born by C-section (CSD), which mimics clinical observations of dysregulated gut microbiota. Animals were either born naturally or by CSD, before being adopted by dams who underwent delivery within the 12 preceding hours. Behavioural

SUBMITTER: Di Miceli M 

PROVIDER: S-EPMC11608364 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature