ASGR1 deficiency improves atherosclerosis but alters liver metabolism in ApoE^-/- mice.

ABSTRACT: The asialoglycoprotein receptor 1 (ASGR1), a multivalent carbohydrate-binding receptor that primarily is responsible for recognizing and eliminating circulating glycoproteins with exposed galactose (Gal) or N-acetylgalactosamine (GalNAc) as terminal glycan residues, has been implicated in modulating the lipid metabolism and reducing cardiovascular disease burden. In this study, we investigated the impact of ASGR1 deficiency (ASGR1^-/-) on atherosclerosis by evaluating its effects on plaque formation, lipid metabolism, circulating immunoinflammatory response, and circulating N-glycome under the hypercholesterolemic condition in ApoE-deficient mice. After 16 weeks of a western-type diet, ApoE^-/-/ASGR1^-/- mice presented lower plasma cholesterol and triglyceride

SUBMITTER: Svecla M 

PROVIDER: S-EPMC11608471 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature