The challenges of hepatic epithelioid hemangioendothelioma: the diagnosis and current treatments of a problematic tumor.

ABSTRACT: Hepatic epithelioid hemangioendothelioma (HEHE) is a malignant vascular tumor known for its rarity. The different types of this hepatic tumor (single, multiple-nodular or diffused) indicate different prognosis and treatment plans. However, the heterogenic clinical manifestation creates a dilemma and a wide range of challenges when attending to HEHE patients. This review addresses the unique profile and clinical challenges that complicate the diagnosis and treatment of HEHE while focusing on current therapeutic strategies and their limitations. The unclear etiology is a challenging feature of HEHE. The exact involvement of potential risk factors and mechanism of development are still undefined. Relevant genetic alterations like WWTR1-CAMTA1 fusion have been investigated; however, they are o

SUBMITTER: Atyah MM 

PROVIDER: S-EPMC11608485 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature