Tailored impact of dietary fibers on gut microbiota: a multi-omics comparison on the lean and obese microbial communities.

ABSTRACT: Previous studies have shown that microbial communities differ in obese and lean individuals, and dietary fiber can help reduce obesity-related conditions through diet-gut microbiota interactions. However, the mechanisms by which dietary fibers shape the gut microbiota still need to be elucidated. In this in vitro study, we examined how apple fibers affect lean and obese microbial communities on a global scale. We employed a high-throughput micro-matrix bioreactor system and a multi-omics approach to identify the key microorganisms and metabolites involved in this process. Initially, metagenomics and metabolomics data indicated that obese and lean microbial communities had distinct starting microbial communities. We found that obese microbial community had different characteristics, includi

SUBMITTER: Dell'Olio A 

PROVIDER: S-EPMC11608498 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature