Correlation between gut microbiota and pancreatitis: a bidirectional Mendelian randomization.

ABSTRACT:

Objective

The causative role of gut microbiota in pancreatitis remains unknown. This study aimed to investigate potential causal associations between gut microbiota and pancreatitis, using bidirectional Mendelian randomization (MR) analysis.

Methods

We analyzed genome-wide association study (GWAS) summary statistics for gut microbiota (211 taxa from gut microbiota, n = 18 340) and two types of pancreatitis, namely acute pancreatitis (AP, 5509 cases and 301 383 controls) and chronic pancreatitis (CP, 3002 cases and 301 383 controls). A reverse MR analysis was also performed to assess the possibility of reverse causation.

Results

Nine features (one family + eight genera) showed a causal association with AP. According to inverse-variance weighted (IVW) estimates, phylum

SUBMITTER: Nan B 

PROVIDER: S-EPMC11608590 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature