Mirtazapine in pregnancy and lactation: A systematic review of adverse outcomes.

ABSTRACT:

Introduction

Peripartum depression is common and treatment with mirtazapine may be indicated. However, evidence on its safety in pregnancy and lactation is fragmented. The objective of this systematic review was to evaluate the literature on the safety of mirtazapine in pregnancy and lactation.

Methods

PubMed, Embase, Medline, PsycInfo, and clinicaltrials.gov were searched for 'antidepressants' or 'mirtazapine' in combination with 'pregnancy', 'lactation' or 'offspring'. No restrictions on type of study were applied and selection was performed by two independent reviewers using Covidence. Two reviewers extracted data and performed risk of bias assessment and evidence synthesis was performed for each outcome individually. The protocol was registered at PROSPERO (registration

SUBMITTER: Ostenfeld A 

PROVIDER: S-EPMC11608810 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature