The relationship between childhood adversity and affective instability across psychiatric disorders: A meta-analysis.

ABSTRACT:

Introduction

Affective instability represents an important, transdiagnostic biobehavioural dimension of mental ill health and clinical outcome. The causes of affective instability remain unclear. This systematic review and meta-analysis evaluated the extent to which exposure to childhood adversity is associated with affective instability across psychiatric disorders, and which forms of adversity are most strongly associated with affective instability.

Methods

The review followed a published protocol (PROSPERO: CRD42020168676). Searches in Medline, Embase and PsychInfo identified studies using quantitative measures of childhood adversity and affective instability, published between January 1980 and July 2023. Data were analysed using a random effects meta-analysis separately

SUBMITTER: Palmier-Claus J 

PROVIDER: S-EPMC11608813 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature