T-cell-related skin inflammatory flareups with Th1 polarity in a patient with pseudoxanthoma elasticum.

ABSTRACT: Pseudoxanthoma elasticum (PXE) is a genetic disorder characterized by ectopic calcification of tissues rich in elastic fibres (OMIM 264800). To date, PXE is considered a metabolic disease linked to an imbalance between pro- and anti-calcifying factors. The occurrence of sporadic erythematous flareups of PXE skin lesions is a complaint that we heard about on several occasions at the French PXE reference centre. However, this rare clinical aspect had never been extensively studied. We have had the opportunity to investigate a 13-year-old patient experiencing an erythematous flareup of his PXE lesions. We conducted this work to identify what type of inflammation was implicated in his lesions. An incisional skin biopsy on a recent erythematous inguinal PXE lesion was performed and sent for his

SUBMITTER: Rocour S 

PROVIDER: S-EPMC11608869 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature