Tissue Cadherin 17 (CDH17): An Important Prognostic Determinant of Colorectal Cancer Using Digital Image Analysis.

ABSTRACT:

Background

Colorectal cancer (CRC) is a commonly diagnosed malignancy with significant mortality rates worldwide. The identification of robust prognostic biomarkers for prediction of survival outcomes and recurrence can aid disease management and improve patients' quality of living.

Aim

This study aimed to investigate the prognostic value of cadherin 17 (CDH17) tissue expression in CRC patients by utilizing a standardized automated immunohistochemistry (IHC) platform integrated with a digitalized scoring system.

Methods and results

IHC was conducted to assess CDH17 expression on tumor tissues obtained from 150 retrospective CRC cases. A computer-assisted imaging analysis was performed to quantify CDH17 tissue expression using an IHC scoring algorithm known as the Memb

SUBMITTER: Ng L 

PROVIDER: S-EPMC11608892 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature