Effects of transient, persistent, and resurgent sodium currents on excitability and spike regularity in vestibular ganglion neurons.

ABSTRACT: Vestibular afferent neurons occur as two populations with differences in spike timing regularity that are independent of rate. The more excitable regular afferents have lower current thresholds and sustained spiking responses to injected currents, while irregular afferent neurons have higher thresholds and transient responses. Differences in expression of low-voltage-activated potassium (K_LV) channels are emphasized in models of spiking regularity and excitability in these neurons, leaving open the potential contributions of the voltage-gated sodium (Na_V) channels responsible for the spike upstroke. We investigated the impact of different Na_V current modes (transient, persistent, and resurgent) with whole-cell patch clamp experiments in mouse vestibular gan

SUBMITTER: Baeza-Loya S 

PROVIDER: S-EPMC11608953 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature